{"id":2801,"date":"2021-08-03T11:30:09","date_gmt":"2021-08-03T02:30:09","guid":{"rendered":"https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/?page_id=2801"},"modified":"2021-10-08T14:23:26","modified_gmt":"2021-10-08T05:23:26","slug":"matsubara","status":"publish","type":"page","link":"https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/matsubara\/","title":{"rendered":"MATSUBARA LAB"},"content":{"rendered":"\n<div class=\"wp-block-vk-blocks-outer vkb-outer-472cb5e7-bdfb-4e9f-a39d-0f9320bfe390 vk_outer vk_outer-width-full vk_outer-paddingLR-use vk_outer-paddingVertical-use vk_outer-bgPosition-normal\"><style>.vkb-outer-472cb5e7-bdfb-4e9f-a39d-0f9320bfe390{background: linear-gradient(rgba(246, 243, 238, 0.5), rgba(246, 243, 238, 0.5)); }<\/style><div><div class=\"vk_outer_container\">\n<div class=\"wp-block-vk-blocks-heading\"><div class=\"vk_heading vk_heading-style-default\"><h1 style=\"font-size:3.6rem\" class=\"vk_heading_title vk_heading_title-style-default\"><span class=\"under raleway spfont\">MATSUBARA LAB <\/span><\/h1><\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/matsubara.png\"><img loading=\"lazy\" decoding=\"async\" width=\"972\" height=\"724\" src=\"https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/matsubara.png\" alt=\"\" class=\"wp-image-2805\" srcset=\"https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/matsubara.png 972w, https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/matsubara-300x223.png 300w, https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/matsubara-768x572.png 768w\" sizes=\"auto, (max-width: 972px) 100vw, 972px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h4 class=\"add\">\u226b <strong>PROFILE<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table alignleft b_less\"><table class=\"row_table\"><tbody><tr><td class=\"b\">2001\u5e74\u3000<\/td><td>\u5927\u962a\u5927\u5b66 \u6b6f\u5b66\u90e8\u6b6f\u5b66\u79d1 \u5352\u696d<\/td><\/tr><tr><td rowspan=\"2\" valign=\"top\" class=\"b\">2005\u5e74<\/td><td>\u5927\u962a\u5927\u5b66 \u5927\u5b66\u9662\u6b6f\u5b66\u7814\u7a76\u79d1 \u4fee\u4e86<\/td><\/tr><tr>\n\t  <td>\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u6b6f\u5b66\u7814\u7a76\u79d1 COE \u535a\u58eb\u7814\u7a76\u54e1<\/td><\/tr><tr><td class=\"b\">2008\u5e74<\/td><td class=\"prompt\">Harvard school of Dental Medicine (Department of Infection and Immunity) Research fellow<\/td><\/tr><tr><td class=\"b\">2012\u5e74<\/td><td>\u6771\u5317\u5927\u5b66 \u77ef\u6b63\u6b6f\u79d1 \u75c5\u9662\u52a9\u6559<\/td><\/tr><tr>\n\t    <td class=\"b\">2015\u5e74<\/td><td>\u4e5d\u5dde\u6b6f\u79d1\u5927\u5b66 \u5065\u5eb7\u5897\u9032\u5b66\u8b1b\u5ea7 \u5206\u5b50\u60c5\u5831\u751f\u5316\u5b66\u5206\u91ce \u52a9\u6559<\/td><\/tr><tr>\n\t      <td class=\"b\">2019\u5e74<\/td><td>\u4e5d\u5dde\u6b6f\u79d1\u5927\u5b66 \u5065\u5eb7\u5897\u9032\u5b66\u8b1b\u5ea7 \u5206\u5b50\u60c5\u5831\u751f\u5316\u5b66\u5206\u91ce \u51c6\u6559\u6388<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"add\">\u226b <strong>LAB MEMBERS<\/strong><\/h4>\n\n\n\n<p class=\"prompt wp-block-paragraph\">KAZUMA\u3000YASUDA\uff08\u5b89\u7530\u3000\u548c\u771f\uff09\u2026\uff3bGraduate Student, \u5927\u5b66\u9662\u751f\uff3d<br>KANA\u3000MIZUTA\uff08\u6c34\u7530\u3000\u594f\uff09\u2026\uff3bGraduate Student, \u5927\u5b66\u9662\u751f\uff3d<br>HIROKA\u3000KAWAUE\uff08\u5ddd\u4e0a\u3000\u7d18\u4f73\uff09\u2026\uff3bGraduate Student, \u5927\u5b66\u9662\u751f\uff3d<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"add\">\u226b <strong>OUR RESEARCH<\/strong><\/h4>\n\n\n\n<h6><strong>\uff11\uff0e\u9aa8\u4ee3\u8b1d\u7814\u7a76<\/strong><\/h6>\n\n\n\n<p class=\"prompt wp-block-paragraph\">\u3000\u9aa8\u306f\u7269\u7406\u7684\u306b\u4f53\u3092\u652f\u3048\u308b\u7d44\u7e54\u3067\u3001\u6b6f\u79d1\u95a2\u9023\u306b\u304a\u3044\u3066\u3082\u6b6f\u3092\u652f\u3048\u308b\u6b6f\u69fd\u9aa8\u306e\u6a5f\u80fd\u306f\u91cd\u8981\u3067\u3059\u3002\u307e\u305f\u9aa8\u306f\u7b4b\u8089\u306e\u52d5\u304d\u3084\u69d8\u3005\u306a\u751f\u4f53\u53cd\u5fdc\u306b\u6b20\u304b\u305b\u306a\u3044\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3059\u308b\u6a5f\u95a2\u3067\u3059\u3002\u8840\u6db2\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3059\u308b\u305f\u3081\u306b\u3001\u9aa8\u306f\u5e38\u306b\u7834\u58ca\u3068\u5f62\u6210\uff08\u9aa8\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\uff09\u3092\u7e70\u308a\u8fd4\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u9aa8\u306e\u7834\u58ca\u306f\u7834\u9aa8\u7d30\u80de\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u304c\u3001\u9aa8\u306e\u5f62\u6210\u306b\u306f\u9aa8\u82bd\u7d30\u80de\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u304c\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u7834\u9aa8\u7d30\u80de\u3068\u9aa8\u82bd\u7d30\u80de\u306f\u304a\u4e92\u3044\u306b\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u3092\u3068\u308a\u306a\u304c\u3089\u3001\u8840\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3068\u9aa8\u7d44\u7e54\u3092\u3046\u307e\u304f\u7dad\u6301\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u308b\u3068\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3084\u5927\u7406\u77f3\u9aa8\u75c5\u3001\u53e3\u8154\u95a2\u9023\u3067\u306f\u6b6f\u5468\u75c5\u306a\u3069\u306e\u75c5\u6c17\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u7834\u9aa8\u7d30\u80de\u3084\u9aa8\u82bd\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u5206\u5b50\u7684\u306b\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h6><strong>1\uff0d\uff11\u3000\u7834\u9aa8\u7d30\u80de<\/strong><\/h6>\n\n\n\n<p class=\"prompt wp-block-paragraph\">\u3000\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3084\u6b6f\u5468\u75c5\u306a\u3069\u9aa8\u306b\u95a2\u3059\u308b\u4ee3\u8b1d\u6027\u9aa8\u75be\u60a3\u306b\u306f\u3001\u7834\u9aa8\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u4ea2\u9032\u3059\u308b\u75be\u60a3\u304c\u591a\u304f\u5b58\u5728\u3057\u307e\u3059\u3002\u7834\u9aa8\u7d30\u80de\u304c\u9aa8\u5438\u53ce\u3092\u304a\u3053\u306a\u3046\u306b\u306f\u3001\u300c\u7834\u9aa8\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u300d\u3001\u300c\u7834\u9aa8\u7d30\u80de\u304c\u9aa8\u306b\u63a5\u7740\u3059\u308b\u300d\u3001\u300c\u7834\u9aa8\u7d30\u80de\u304c\u9178\u3084\u57fa\u8cea\u5206\u89e3\u9175\u7d20\u306b\u3088\u308a\u9aa8\u57fa\u8cea\u3092\u5206\u89e3\u3059\u308b\u300d\u306e3\u30b9\u30c6\u30c3\u30d7\u3092\u8981\u3057\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3001\u7834\u9aa8\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\u30d3\u30b9\u30db\u30b9\u30d5\u30a9\u30cd\u30fc\u30c8\u88fd\u5264\u3084\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u3092\u6291\u5236\u3059\u308b\u6297RANKL\u6297\u4f53\u306a\u3069\u3001\u7834\u9aa8\u7d30\u80de\u3092\u7121\u304f\u3057\u3066\u76f8\u5bfe\u7684\u306b\u9aa8\u5f62\u6210\u3092\u512a\u4f4d\u306b\u3059\u308b\u85ac\u5264\u304c\u30e1\u30a4\u30f3\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u6cbb\u7642\u6cd5\u3067\u306f\u6b6f\u79d1\u3067\u554f\u984c\u8996\u3055\u308c\u3066\u3044\u308b\u984e\u9aa8\u58ca\u6b7b\u306a\u3069\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u8d77\u304d\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u7834\u9aa8\u7d30\u80de\u304c\u306a\u3044\u305f\u3081\u306b\u9aa8\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u7570\u5e38\u3092\u304d\u305f\u3057\u3066\u3044\u308b\u306e\u304c\u4e00\u56e0\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u7834\u9aa8\u7d30\u80de\u304c\u5b58\u5728\u3057\u305f\u307e\u307e\u9aa8\u5438\u53ce\u6a5f\u80fd\u3092\u5236\u5fa1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308c\u3070\u3001\u6709\u5bb3\u4e8b\u8c61\u304c\u8efd\u6e1b\u3055\u308c\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><a href=\"https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/b267f92fc9ca8308542f560c975eeb4a.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/b267f92fc9ca8308542f560c975eeb4a-1024x729.jpg\" alt=\"\" class=\"wp-image-2821\" width=\"256\" height=\"182\" srcset=\"https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/b267f92fc9ca8308542f560c975eeb4a-1024x729.jpg 1024w, https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/b267f92fc9ca8308542f560c975eeb4a-300x214.jpg 300w, https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/b267f92fc9ca8308542f560c975eeb4a-768x547.jpg 768w, https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/b267f92fc9ca8308542f560c975eeb4a-1536x1093.jpg 1536w, https:\/\/www2.kyu-dent.ac.jp\/dept\/biochem\/wp-content\/uploads\/2021\/08\/b267f92fc9ca8308542f560c975eeb4a.jpg 2012w\" sizes=\"auto, (max-width: 256px) 100vw, 256px\" \/><\/a><figcaption><meta charset=\"utf-8\">[\u56f3]<br>\u7834\u9aa8\u7d30\u80de\u306f\u9aa8\u57fa\u8cea\u306b\u63a5\u7740\u3059\u308b\u305f\u3081\u306b\u30a2\u30af\u30c1\u30f3\u30ea\u30f3\u30b0\u3068\u3044\u3046\u7279\u6b8a\u306a\u7d30\u80de\u9aa8\u683c\u69cb\u9020\u3092\u3068\u308b\u3002<\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"prompt wp-block-paragraph\">\u3000\u79c1\u306f\u3053\u308c\u307e\u3067\u7834\u9aa8\u7d30\u80de\u306e\u9aa8\u57fa\u8cea\u3078\u306e\u63a5\u7740\u306b\u95a2\u3057\u3066\u7814\u7a76\u3092\u4e2d\u5fc3\u306b\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7834\u9aa8\u7d30\u80de\u306e\u7d30\u80de\u63a5\u7740\u306b\u306fSrc\u3068\u3044\u3046\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u304a\u3053\u306a\u3063\u3066\u3044\u307e\u3059\u3002Src\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306f\u3001\u7834\u9aa8\u7d30\u80de\u304c\u5b58\u5728\u3057\u3001\u9178\u3084\u57fa\u8cea\u5206\u89e3\u9175\u7d20\u3092\u7523\u751f\u3059\u308b\u80fd\u529b\u304c\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9aa8\u57fa\u8cea\u306b\u3046\u307e\u304f\u63a5\u7740\u3067\u304d\u305a\u306b\u9aa8\u5438\u53ce\u304c\u884c\u308f\u308c\u306a\u3044\u305f\u3081\u3001\u5927\u7406\u77f3\u9aa8\u75c5\u3092\u5448\u3057\u307e\u3059\u3002\u3053\u306eSrc\u304c\u3069\u306e\u3088\u3046\u306b\u7834\u9aa8\u7d30\u80de\u306e\u63a5\u7740\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3067\u304d\u308c\u3070\u4ee3\u8b1d\u6027\u9aa8\u75be\u60a3\u306e\u6cbb\u7642\u6cd5\u306e\u767a\u5c55\u306b\u3064\u306a\u304c\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3001Src\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u5206\u5b50\u30b7\u30b0\u30ca\u30eb\u306e\u89e3\u660e\u3092\u76ee\u7684\u306b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306bSrc\u306e\u4e0b\u6d41\u3067\u50cd\u304fCortactin (T. Matsubara, et. al., J. Bone Miner. 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Matsubara<\/u>, T. Yaginuma, W.N. Addison, Y. Fujita, K. Watanabe, I. Yoshioka, H. Hikiji, K. Maki, R. Baron, S. Kokabu, Plectin stabilizes microtubules during osteoclastic bone resorption by acting as a scaffold for Src and Pyk2, Bone. 132 (2020) 115209. https:\/\/doi.org\/10.1016\/j.bone.2019.115209.<\/p>\n\n\n\n<p class=\"prompt\">[2]\u3000<u>T. Matsubara<\/u>, S. Kokabu, C. Nakatomi, M. Kinbara, T. Maeda, M. Yoshizawa, H. Yasuda, T. Takano-Yamamoto, R. Baron, E. Jimi, The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin Organization, and Bone Resorption Activity of Osteoclasts, Mol. Cell. Biol. 38 (2018) e00425-17. https:\/\/doi.org\/10.1128\/MCB.00425-17.<\/p>\n\n\n\n<p class=\"prompt\">[3]\u3000<u>T. Matsubara<\/u>, M. Kinbara, T. Maeda, M. Yoshizawa, S. Kokabu, T. Takano Yamamoto, Regulation of osteoclast differentiation and actin ring formation by the cytolinker protein plectin, Biochem. Biophys. Res. Commun. 489 (2017) 472\u2013476. https:\/\/doi.org\/10.1016\/j.bbrc.2017.05.174.<\/p>\n\n\n\n<p class=\"prompt\">[4]\u3000<u>T. Matsubara<\/u>, F. Ikeda, K. Hata, M. Nakanishi, M. Okada, H. Yasuda, R. Nishimura, T. Yoneda, Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts, J. Bone Miner. Res. 25 (2010) 1068\u20131076. https:\/\/doi.org\/10.1359\/jbmr.091039.<\/p>\n\n\n\n<p class=\"prompt\">[5]\u3000<u>T. Matsubara<\/u>, K. Kida, A. Yamaguchi, K. Hata, F. Ichida, H. Meguro, H. Aburatani, R. Nishimura, T. Yoneda, BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation, J. Biol. 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